Neutrophilic Dermatoses

Anthony D. Ormerod, Philip J. Hampton


Pyoderma gangrenosum is a rare, non‐infectious, neutrophilic dermatosis commonly associated with underlying systemic disease. Diagnosis is based on typical clinical features and the exclusion of other cutaneous ulcerating diseases. It is most often encountered as the classic type but several variants also need to be distinguished. Its course may be protracted and recurrent with significant morbidity and mortality. Milder cases can respond to simple topical measures but frequently, potent immunosuppressive therapies, combined therapies or biologicals including antitumour necrosis factor treatment are required to achieve healing.
Keywords pyoderma gangrenosum, Sweet neutrophilic dermatosis, bowel‐associated dermatitis–arthritis syndrome, subcorneal pustular dermatosis, neutrophilic dermatosis of the dorsal hand, pyodermatitis vegetans, amicrobial pustulosis of the skin folds, aseptic abscess syndrome


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