Histopathology of the Skin: General Principles

Eduardo Calonje, Balbir S. Bhogal


This chapter describes in detail the steps followed from the moment a skin biopsy is taken through to the final step when interpretation of the changes is performed by the histopathologist. It emphasizes laboratory methods including special techniques useful to reach a diagnosis, potential artefacts and the approach to the interpretation of skin biopsies.
Keywords skin biopsy, histology, light microscopy, electron microscopy, histochemistry, artefacts, immunofluorescence, direct immunofluorescence, indirect immunofluorescence, immunohistochemistry


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